Publications
2023 Publications
Sage AT, Donahoe LL, Shamandy AA, Mousavi SH, Chao BT, Zhou X, Valero J, Balachandran S, Ali A, Martinu T, Tomlinson G, Del Sorbo L, Yeung JC, Liu M, Cypel M, Wang B, Keshavjee S. A machine-learning approach to human ex vivo lung perfusion predicts transplantation outcomes and promotes organ utilization. Nat Commun. 2023 Aug 9;14<(1):4810 doi:10.1038/s41467-023-40468-7. PubMed PMID: 37558674; PubMed Central PMCID: PMC10412608.
Chao BT, Sage AT, Yeung JC, Bai X, Ma J, Martinu T, Liu M, Cypel M, Van Raemdonck D, Ceulemans LJ, Neyrinck A, Verleden S, Keshavjee S. Identification of regional variation in gene expression and inflammatory proteins in donor lung tissue and ex vivo lung perfusate. J Thorac Cardiovasc Surg. 2023 Jul 21;. doi: 10.1016/j.jtcvs.2023.07.013. [Epub ahead of print] PubMed PMID: 37482240.
Sage AT, Peel J, Valero J, Yeung JC, Liu M, Cypel M, Sander B, Keshavjee S. Time to extubation for lung transplant recipients represents a pragmatic end-point to guide the development of prognostic tests. J Heart Lung Transplant. 2023 Jul 3;. doi: 10.1016/j.healun.2023.06.019. [Epub ahead of print] PubMed PMID: 37406839.
Ramendra R, Sage AT, Yeung J, Fernandez-Castillo JC, Cuesta M, Aversa M, Liu M, Cypel M, Keshavjee S, Martinu T. Triaging donor lungs based on a microaspiration signature that predicts adverse recipient outcome. J Heart Lung Transplant. 2023 Apr;42(4):456-465. doi: 10.1016/j.healun.2022.12.024. Epub 2023 Jan 6. PubMed PMID: 36710092.
Ishiwata T, Sage AT, Fujino K, Mohammed N, Inage T, Bernards N, Keshavjee S, Yasufuku K. A Biomarker-Based Approach for the Determination of Sample Adequacy During Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: A Proof of Concept Study. Chest. 2023 Jan;163(1):255-258. doi: 10.1016/j.chest.2022.07.003. Epub 2022 Jul 13. PubMed PMID: 35841933.
Sage AT, Cypel M, Cardinal M, Qiu J, Humar A, Keshavjee S. Testing the delivery of human organ transportation with drones in the real world. Sci Robot. 2022 Dec 21;7(73):eadf5798. doi: 10.1126/scirobotics.adf5798. Epub 2022 Dec 21. Review. PubMed PMID: 36542685.
Husain S, Sage AT, Del Sorbo L, Cypel M, Martinu T, Juvet SC, Mariscal A, Wright J, Chao BT, Shamandy AA, Mousavi SH, Ma J, Wang B, Valero J, Liu M, Landes M, Balachandran S, Hudson K, Ngai M, Capuano M, Gelardi M, Lupia E, Marinowic DR, Friedrich FO, Schmitz CRR, Dos Santos LSM, Barbe-Tuana FM, Jones MH, Kain KC, Mazzulli T, Sabbah S, Keshavjee S. A biomarker assay to risk-stratify patients with symptoms of respiratory tract infection. Eur Respir J. 2022 Dec;60(6). doi: 10.1183/13993003.00459-2022. Print 2022 Dec. PubMed PMID: 36104292; PubMed Central PMCID: PMC9753477.
Zhang CYK, Ahmed M, Huszti E, Levy L, Hunter SE, Boonstra KM, Moshkelgosha S, Sage AT, Azad S, Ghany R, Yeung JC, Crespin OM, Singer LG, Keshavjee S, Martinu T. Utility of bile acids in large airway bronchial wash versus bronchoalveolar lavage as biomarkers of microaspiration in lung transplant recipients: a retrospective cohort study. Respir Res. 2022 Aug 26;23(1):219. doi: 10.1186/s12931-022-02131-5. PubMed PMID: 36028826; PubMed Central PMCID: PMC9419323.
Nykänen AI, Mariscal A, Duong A, Estrada C, Ali A, Hough O, Sage A, Chao BT, Chen M, Gokhale H, Shan H, Bai X, Zehong G, Yeung J, Waddell T, Martinu T, Juvet S, Cypel M, Liu M, Davies JE, Keshavjee S. Engineered mesenchymal stromal cell therapy during human lung ex vivo lung perfusion is compromised by acidic lung microenvironment. Mol Ther Methods Clin Dev. 2021 Dec 10;23:184-197. doi: 10.1016/j.omtm.2021.05.018. eCollection 2021 Dec 10. PubMed PMID: 34703841; PubMed Central PMCID: PMC8516994.
Di Nardo M, Del Sorbo L, Sage A, Ma J, Liu M, Yeung JC, Valero J, Ghany R, Cypel M, Keshavjee S. Predicting donor lung acceptance for transplant during ex vivo lung perfusion: The EX vivo lung PerfusIon pREdiction (EXPIRE). Am J Transplant. 2021 Nov;21(11):3704-3713. doi: 10.1111/ajt.16616. Epub 2021 Jun 11. PubMed PMID: 33872459.
Sage AT, Richard-Greenblatt M, Zhong K, Bai XH, Snow MB, Babits M, Ali A, Baciu C, Yeung JC, Liu M, Cypel M, Kain KC, Keshavjee S. Prediction of donor related lung injury in clinical lung transplantation using a validated ex vivo lung perfusion inflammation score. J Heart Lung Transplant. 2021 Jul;40(7):687-695. doi: 10.1016/j.healun.2021.03.002. Epub 2021 Mar 5. PubMed PMID: 33781664.
Baciu C, Sage A, Zamel R, Shin J, Bai XH, Hough O, Bhat M, Yeung JC, Cypel M, Keshavjee S, Liu M. Transcriptomic investigation reveals donor-specific gene signatures in human lung transplants. Eur Respir J. 2021 Apr;57(4). doi: 10.1183/13993003.00327-2020. Print 2021 Apr. PubMed PMID: 33122335.
Zhang CYK, Ahmed M, Huszti E, Levy L, Hunter SE, Boonstra KM, Moshkelgosha S, Sage AT, Azad S, Zamel R, Ghany R, Yeung JC, Crespin OM, Frankel C, Budev M, Shah P, Reynolds JM, Snyder LD, Belperio JA, Singer LG, Weigt SS, Todd JL, Palmer SM, Keshavjee S, Martinu T. Bronchoalveolar bile acid and inflammatory markers to identify high-risk lung transplant recipients with reflux and microaspiration. J Heart Lung Transplant. 2020 Sep;39(9):934-944. doi: 10.1016/j.healun.2020.05.006. Epub 2020 May 19. PubMed PMID: 32487471; PubMed Central PMCID: PMC7483994.
Caldarone L, Mariscal A, Sage A, Khan M, Juvet S, Martinu T, Zamel R, Cypel M, Liu M, Palaniyar N, Keshavjee S. Neutrophil extracellular traps in ex vivo lung perfusion perfusate predict the clinical outcome of lung transplant recipients. Eur Respir J. 2019 Apr;53(4). doi: 10.1183/13993003.01736-2018. Print 2019 Apr. PubMed PMID: 30655281.
Sage AT, Bai X, Cypel M, Liu M, Keshavjee S, Kelley SO. Using the inherent chemistry of the endothelin-1 peptide to develop a rapid assay for pre-transplant donor lung assessment. Analyst. 2015 Dec 21;140(24):8092-6. doi: 10.1039/c5an01536g. PubMed PMID: 26548776.
Sage AT, Besant JD, Mahmoudian L, Poudineh M, Bai X, Zamel R, Hsin M, Sargent EH, Cypel M, Liu M, Keshavjee S, Kelley SO. Fractal circuit sensors enable rapid quantification of biomarkers for donor lung assessment for transplantation. Sci Adv. 2015 Aug;1(7):e1500417. doi: 10.1126/sciadv.1500417. eCollection 2015 Aug. PubMed PMID: 26601233; PubMed Central PMCID: PMC4643795.
Zhou YG, Wan Y, Sage AT, Poudineh M, Kelley SO. Effect of microelectrode structure on electrocatalysis at nucleic acid-modified sensors. Langmuir. 2014 Dec 2;30(47):14322-8. doi: 10.1021/la502990s. Epub 2014 Nov 20. PubMed PMID: 25377873.
Sage AT, Besant JD, Lam B, Sargent EH, Kelley SO. Ultrasensitive electrochemical biomolecular detection using nanostructured microelectrodes. Acc Chem Res. 2014 Aug 19;47(8):2417-25. doi: 10.1021/ar500130m. Epub 2014 Jun 25. PubMed PMID: 24961296.
Poudineh M, Mohamadi RM, Sage A, Mahmoudian L, Sargent EH, Kelley SO. Three-dimensional, sharp-tipped electrodes concentrate applied fields to enable direct electrical release of intact biomarkers from cells. Lab Chip. 2014 May 21;14(10):1785-90. doi: 10.1039/c4lc00144c. Epub 2014 Apr 3. PubMed PMID: 24695906.
Lam B, Holmes RD, Das J, Poudineh M, Sage A, Sargent EH, Kelley SO. Optimized templates for bottom-up growth of high-performance integrated biomolecular detectors. Lab Chip. 2013 Jul 7;13(13):2569-75. doi: 10.1039/c3lc41416g. Epub 2013 Mar 1. PubMed PMID: 23455732.
Lam B, Das J, Holmes RD, Live L, Sage A, Sargent EH, Kelley SO. Solution-based circuits enable rapid and multiplexed pathogen detection. Nat Commun. 2013;4:2001. doi: 10.1038/ncomms3001. PubMed PMID: 23756447.
Sage AT, Holtby-Ottenhof S, Shi Y, Damjanovic S, Sharma AM, Werstuck GH. Metabolic syndrome and acute hyperglycemia are associated with endoplasmic reticulum stress in human mononuclear cells. Obesity (Silver Spring). 2012 Apr;20(4):748-55. doi: 10.1038/oby.2011.144. Epub 2011 Jun 2. PubMed PMID: 21633399.
Sage AT, Walter LA, Shi Y, Khan MI, Kaneto H, Capretta A, Werstuck GH. Hexosamine biosynthesis pathway flux promotes endoplasmic reticulum stress, lipid accumulation, and inflammatory gene expression in hepatic cells. Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E499-511. doi: 10.1152/ajpendo.00507.2009. Epub 2009 Dec 1. PubMed PMID: 19952345.